How To Lose Money With BIOARTIFICIAL LIVER

How To Make Your BIOARTIFICIAL LIVER

Introduction

This study based on bioartificial liver will describe its importance, current market trends and new designs to improve the functionality of bioartificial liver. Furthermore, before a comprehensive discussion on the bioprosthetic liver, a background on the structure, function, anatomy, and defects of the liver will be discussed. Afterwards, the study will discuss the importance of Bioprosthetic and Artificial Liver and then the study will proceed to discuss Bioprosthetic Liver, their current market status and improvement strategies.

Background and Significance

liver function

Liver which is the largest internal organ of the human body and the second largest organ weighing 1.5 kg (approx) performs a variety of functions (Rad, 2020). The various functions of the liver are discussed below.

Functions related to blood and circulation: During the embryonic stage, it plays a role in RBC formation while in adults, it plays a role in RBC destruction. In addition, it produced prothrombin, fibrinogen, and heparin which are essential for clotting (Rad, 2020). simultaneously

Carbohydrate and protein and ketone body composition. In addition, it accumulates fat.

Functions related to protein metabolism: Liver is the main site of urea formation, uric acid formation, plasma protein and nitrogen metabolism, urea synthesis etc.

Basic Anatomy, Physiology of Liver

The liver is divided into left and right lobes by the presence of the falciform ligament. In addition, from the right lobe, two other accessory lobes arise called the caudate lobe and the quadrate lobe.

The caudate lobe is located on the upper part of the visceral surface of the liver between the inferior vena cava and the fossa, arising from the presence of the ligamentum venosum. On the other hand, the quadrate lobe is located on the lower part of the visceral surface of the liver between the fossa formed by the gallbladder and the ligamentum teres. In addition, the caudate and quadrate lobes are separated by the porta hepatis, which carries nerves, ducts, and vessels into and out of the liver (May 2018).

Diseases/conditions causing liver failure

Hepatitis: Viruses like hepatitis A, B and C cause inflammation of the liver. Although it is non-infectious, it is also caused by illegal drugs, allergic reactions, excessive alcohol consumption, and obesity (Rad, 2020).

Cirrhosis: This is a condition in which regenerated liver cells aggregate and form bands of scar tissue or deposition of collagen tissues, causing damage and death of liver cells. Chronic hepatitis infection, chronic alcoholism, genetic metabolic diseases are some of the causes of cirrhosis. Also, due to cirrhosis, the liver function stops completely.

Liver damage: This is either due to liver disease or liver intoxication or due to chronic diseases.

Jaundice: The level of bile pigment increases excessively with the level of bilirubin. Jaundice has many causes, however, two common causes are diseases of the liver and biliary tract.

Hemochromatosis: liver failure due to accumulation of iron in the liver

Primary sclerosing cholangitis: a rare disease that causes scarring and inflammation in the bile ducts of the liver

Primary biliary cirrhosis: The bile ducts are destroyed and permanent scarring of the liver occurs and develops.

Treatment: is it necessary?

(Red, 2020) Liver failure or liver cirrhosis is a global problem. However, it is found in Egypt, Sierra Leone, Nigeria, Ethiopia and more (WHO, 2020).

Furthermore, from 2000–2015, it was found that in the United States alone, the death rate associated with chronic liver disease with cirrhosis increased by 31%, especially among those aged 45–64 (CDC, 2017). in persons. Furthermore, it was found that the death rate increased by 21% in the 25-44 age group, with women being more affected by the disease than men (CDC, 2017).

Therefore, due to the presence of high mortality due to liver failure, it becomes important to improve its treatment process. Orthotopic liver transplantation is a solution when the liver fails to regenerate. However, artificial and bioprosthetic livers exist to detoxify and mimic liver function in liver failure until liver regeneration begins or until a donor organ becomes available.

Importance of Biosynthetic vs Synthetic

Showing the difference between artificial and bioprosthetic liver support systems

Hepatic function

Synthetic; It performs detoxification process with efficient removal of accumulated toxins. Thus, it allows the natural process of liver regeneration while bioartificial can perform different liver functions. it can perform both synthetic and 

Furthermore, before a comprehensive discussion on the bioprosthetic liver, a background on the structure, function, anatomy, and defects of the liver will be discussed. Afterwards, the study will discuss the importance of Bioprosthetic and Artificial Liver and then the study will proceed to discuss Bioprosthetic Liver, their current market status and improvement strategies. Background and Significance liver function Liver which is the largest internal organ of the human body and the second largest organ weighing 1. Basic Anatomy, Physiology of Liver The liver is divided into left and right lobes by the presence of the falciform ligament. The caudate lobe is located on the upper part of the visceral surface of the liver between the inferior vena cava and the fossa, arising from the presence of the ligamentum venosum. On the other hand, the quadrate lobe is located on the lower part of the visceral surface of the liver between the fossa formed by the gallbladder and the ligamentum teres. In addition, the caudate and quadrate lobes are separated by the porta hepatis, which carries nerves, ducts, and vessels into and out of the liver. Diseases/conditions causing liver failure Hepatitis: Viruses like hepatitis A, B and C cause inflammation of the liver. Jaundice has many causes, however, two common causes are diseases of the liver and biliary tract. Thus, it allows the natural process of liver regeneration while bioartificial can perform different liver functions.it can perform both synthetic .

Furthermore, Furthermore, before a comprehensive discussion on the bioprosthetic liver, a background on the structure, function, anatomy, and defects of the liver will be discussed. Basic Anatomy, Physiology of Liver The liver is divided into left and right lobes by the presence of the falciform ligament. Background and Significance liver function Liver which is the largest internal organ of the human body and the second largest organ weighing 1. Afterwards, the study will discuss the importance of Bioprosthetic and Artificial Liver and then the study will proceed to discuss Bioprosthetic Liver, their current market status and improvement strategies.Diseases/conditions causing liver failure Hepatitis: Viruses like hepatitis A, B and C cause inflammation of the liver. Jaundice has many causes, however, two common causes are diseases of the liver and biliary tract.


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